Our project will focus on developing a rapid diagnostic lateral flow immunoassay that detects Tuberculosis utilizing hydrogel nanoparticles. Incorporating nanoparticle technology is beneficial due to the particles’ strong protein capturing capabilities, protein degradation protection, and amplification of protein concentration. They have high affinity chemical baits dyed to their structure. These dyes include conductive elements which can be exploited using sensor technology. Combining lateral flow diagnostics, hydrogel nanoparticles, and electrical circuitry, low abundance biomarkers produced by the body, such as Tuberculosis, can be detected in a more efficient manner than current rapid diagnostic tests. This project is fulfilling the requirements of the 2017 George Mason University Bioengineering Capstone Project curriculum.